This is a very short tree - just four generations - of a family that lived in London's East End, just outside the walls of the City of London, between about 1676 and 1740.  The family moved around several streets (Paternoster Row, Red Lion Street) in the area of Spittalfields, and attended St Leonard Shoreditch as well as Christchurch, Spittalfields churches. Both Isaac and his only surviving son (also Isaac) were peruke, (or periwig) makers.

It is likely that Isaac (who was born about 1676 according to his age at death), was a son of Isack Appleby and Ann Holmes  who married in 1670 - but only two children of this couple appear in the London baptism registers ... an Ann chr in 1674 at St Leonard Shoreditch and an Edward chr at St Giles Cripplegate in 1687.  The evidence to support this is that Isaac (b~1676) obtained his freedom in the Company of Weavers in 172? on the basis that his father Isaac was granted Freedom of the Company of Weavers in 1671. And the reverse of the youngest Isaac's Apprenticeship indenture mentions that his father was a Weaver. (Note: it was not necessary to join the Company which represented one's actual trade).  So it may be more than a coincidence that Isaac senior's believed mother was Ann Holmes AND his son was apprenticed to a John Holmes.

The descendancy chart for this family paints a sobering picture of life in London's dirty, disease-ridden streets.  Even though his will suggests that Isaac was a well educated tradesman, Isaac and Silence Appleby had nine known children of whom five died in infancy.  His son Isaac and his wife Ann had twelve known children - all four boys died in infancy, and it seems as if only five daughters survived (though I have been unable to discover with certainty if any went on to marry and have children).